Using multiple models for an infectious disease spread we present preliminary epidemiological predictions for the novel coronavirus (2019-nCoV) outbreak.
Impact of oral bile replacement on intestinal mucosa function
We evaluate the impact of oral bile replacement during external biliary drainage on the regenerative capabilities of instentinal mucosa, focusing on enterocytic integrity and mucosa barrier function. The drained biliary fluid undergoes a series of mechanical filtrations with progressively smaller porosity to reduce the bacterial load. The primary clinical markers observed during the therapy include…
Association of a KMT2D mutation with endocrine and hepatobiliary pathology: A case report
We report an unusual case of a Kabuki syndrome associated with biliary atresia and endocrinopathies, and suggest a likely association of the causative mechanisms with the underlying KMT2D mutation. We discuss the pathologies in the context of laboratory, imaging, and modeling data, correlate latest findings of the relevant genetics studies, and outline the prospective therapies.